COEXISTANCE OF ACUTE MYELOID LEUKEMIA (AML-M4) AND HODGKIN'S LYMPHOMA: IMMUNOHISTOCHEMICAL, SKY AND INTERPHASE FISH ANALYSIS.
Bibliographic record
Abstract
We describe a case of 61-year-old man presented with multiple constitutional symptoms and found to have simultaneous occurrence of acute myeloblastic leukemia (AML-M4) and Hodgkin's lymphoma in the cervical lymph node. Peripheral blood (PB) and bone marrow (BM) smears showed typical AML-4 features. Kar-yotyping of the bone marrow revealed many cytogenetic changes including t(16;17) and -Y. SKY analysis show the following clonal pattern 42,X,-Y,der(2)t(2;11)(q37;?), der(5;17) (p10;p10), der(16)t(16;21) (q24;q11),-18, -21. To prove that the Hodgkin's lymphoma of the cervical lymph node is not a leukemic infiltrate and that it is from different clone, interphase fluorescence in situ hybridization (IFISH) was applied on the lymph node biopsy using X and Y centrosome probes revealed absence of loss of chromosome Y. These findings indicated that this patient had a coexistence of AML and Hodgkin's lymphoma. Up to our knowledge this is the first cytogenetically proved case report of a simultaneous occurrence of these two diseases. CLINICAL HISTORY: The patient was a 61-year-old man presented with multiple costitutional symptoms including weight loss, shortness of breath, night sweat and fever. On admission he was found to
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".