P009 Autologous Bone Marrow Transplantation in Refractory Crohn's Disease: A Case Report
Bibliographic record
Abstract
BACKGROUND: IBD comprises Crohn ́s disease (CD) and ulcerative colitis (UC), both are characterized by unpredictable exacerbations and remissions. The incidence is highest in adolescence and early adulthood, and alike other chronic disease, have a considerable impact upon patients' HRQoL. Few studies assessing HRQoL have been performed in adolescents and young adults (AYA) populations.Our objectives were to assess the health-related quality of life (HRQoL) in AYA patients with inflammatory bowel disease (IBD) and analyze the diseases factors that could influence it. METHODS: 59 AYA IBD patients (13-25y) at two gastroenterology units of tertiary hospitals was evaluated and compared to 60 AYA healthy controls (13-25y). 59 AYA IBD patients completed the Pediatric Quality of Life Inventory 4.0 (PedsQL4.0), Short Form Health Survey (SF-36) questionnaires and Pain Visual Scale, according to age. After we compared HRQoL between Crohn’s disease (CD) vs. UC (ulcerative colitis) in AYA population. The demographic data, extra-intestinal manifestation, overlap syndromes, disease active status, treatment and outcomes were also evaluated. All participants and the adolescents' legal guardian written informed consent form. RESULTS: PedsQL4.0 domain "school/ work" and SF-36 domain "general health perception" was reduced in IBD AYA patients compared with healthy controls (P < 0.05). In addition, significantly lower score “health change” in SF-36 in comparison with healthy determined perceived differences in state of health over the past year. No difference in other’s domains and pain scale was observed between CD and UC AYA patients. Disease activity as well extra intestinal manifestations, overlap syndromes, treatments and outcomes did not influence the HRQoL of the AYA patients. Autoimmune sclerosing cholangitis and the use of prednisone were significantly higher among UC patients, whereas previous gut surgery was higher between CD patients. However, these disease factors did not significantly influence the HRQoL between CD vs UC. Mann-Whitney test and Fisher's test were used to compare continuous variables and comparison between groups, P-values were set at 5% (P < 0.05). CONCLUSION: HRQoL was significant lower for AYA with IBD relative to healthy controls. This result highlights areas to focus clinical attention in adolescents and young adult patients with IBD for assessment and future interventions.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.003 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.004 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".