Genotyping and antimicrobial resistance patterns of Mannheimia haemolytica, Pasteurella multocida and Histophilus somni isolated from the upper and lower respiratory tract of feedlot cattle
Bibliographic record
Abstract
In the last 10 years, the prevalence of Pasteurellaceae resistant against drugs typically used for bronchopneumonia (BP) control has increased in feedlot cattle. Surprisingly, it is not clear whether this increase in the prevalence of multidrug resistant (MDR) bacteria is due to the spread of 1 or few multiple MDR clones among cattle during the feeding period (i.e. horizontal spread) or due to the recrudescence of MDR clones already present in the respiratory tract of cattle upon arrival at feedlots. Recently, we reported a high prevalence of MDR M. haemolytica, P. multocida, and H. somni isolated from cattle with BP in 4 feedlots in Western Canada. Unfortunately, as we did not genotype these isolates, it was not possible to determine whether a few or a large number of MDR clones were present in these feedlots, supporting either a horizontal spread of MDR clones among cattle or a recrudescence from carriers. Therefore, the objective was to genotype M. haemolytica, P. multocida, and H. somni isolates using pulsed field gel electrophoresis (PFGE).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".