Aurora kinases promote mitotic progression and asymmetric cell division through activation of Polo kinase
Bibliographic record
Abstract
Organ development and integrity requires the maintenance of a defined and restricted pool of dividing stem cells. This process requires the coupling of mitosis progression to the establishment of stem cells polarization and spindle orientation to ensure that they retain the ability to proliferate while their descendant cells do not proliferate excessively. How this coupling occurs is unknown. Here we show that downstream of Aurora kinases, Polo activity levels are crucial for timely mitotic progression independently from the Spindle Assembly Checkpoint (SAC). In addition, Polo functions downstream of Aurora A to ensure cortical polarity and spindle orientation in neural stem cells, thereby preventing excessive cellular proliferation in developing larval brains, and suppressing tumor development. In addition, induction of aneuploidy in polo mutant brain by inactivation of the SAC leads to an increase in tumor development Altogether, our results reveal that the Aurora-Polo kinase axis is an essential module coupling mitotic progression to asymmetric division in NSCs.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".