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Record W3122091881 · doi:10.1016/j.cell.2020.12.024

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

2021· article· en· W3122091881 on OpenAlexfundno aff
Mirja Tamara Prentzell, Ulrike Rehbein, Marti Cadena Sandoval, Ann‐Sofie De Meulemeester, Ralf Baumeister, Laura Brohée, Bianca Berdel, Mathias Bockwoldt, Bernadette Carroll, Suvagata Roy Chowdhury, Andreas von Deimling, Constantinos Demetriades, Gianluca Figlia, Mariana E. G. de Araújo, Alexander Martin Heberle, Ines Heiland, Birgit Holzwarth, Lukas A. Huber, Jacek Jaworski, Magdalena Kedra, Katharina Kern, Andrii Kopach, Viktor I. Korolchuk, Ineke Kuper, Matylda Macias, Mark Nellist, Wilhelm Palm, Stefan Pusch, José M. Ramos Pittol, Michèle Reil, Anja Reintjes, Friederike Reuter, Julian R. Sampson, Chloë Scheldeman, Aleksandra Siekierska, Eduard Stefan, Aurelio A. Teleman, Laura E. Thomas, Omar Torres‐Quesada, Saskia Trump, Hannah D. West, Peter de Witte, Sandra Woltering, Teodor E. Yordanov, Justyna Zmorzyńska, Christiane A. Opitz, Kathrin Thedieck

Bibliographic record

VenueCell · 2021
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicPI3K/AKT/mTOR signaling in cancer
Canadian institutionsnot available
FundersHorizon 2020Vlaamse regeringKU LeuvenFonds Wetenschappelijk OnderzoekAustrian Science FundMax-Planck-GesellschaftRijksuniversiteit GroningenEuropean Research CouncilMinisterstwo Edukacji i NaukiDeutsche ForschungsgemeinschaftUniversity of BristolFundacja na rzecz Nauki PolskiejMedizinische Universität InnsbruckEuropean CommissionStichting TSC FondsEuropean Molecular Biology OrganizationMedical Research CouncilDepartment of Health and Social CareAcademy of Medical SciencesWellcome TrustHeart of England NHS Foundation TrustCancer Research UKMinistère de l'Économie, de la Science et de l'Innovation - QuébecBritish Skin FoundationUniversität InnsbruckBundesministerium für Bildung und ForschungNational Institute for Health and Care ResearchTuberous Sclerosis AssociationTuberous Sclerosis AllianceDeutsches Krebsforschungszentrum
KeywordsmTORC1BiologyRHEBCell biologyTSC2RegulatorStress granuleZebrafishCrosstalkPI3K/AKT/mTOR pathwaySignal transductionBiochemistryGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.237
Threshold uncertainty score0.387

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.017
GPT teacher head0.257
Teacher spread0.240 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations150
Published2021
Admission routes1
Has abstractno

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