Ultra‐high frequency 70 Mhz ultrasound and IVCM are useful for diagnostic and therapeutic management of atypical Terrien's marginal degeneration
Bibliographic record
Abstract
Abstract Purpose Terrien's marginal degeneration is a rare corneal disease usually characterized by an «insidious thinning of the cornea near the limbus» (Pouliquen Y et al. 1989). Its diagnosis remains essentially clinical. Aim To present the help of innovating imaging in an atypical cystic presentation of Terrien's marginal degeneration. Methods An 87‐year‐old caucasian patient presented since several month a voluminous cystic lesion of the limbus, bulky, neo‐vascularized, in the inferior part of the eye, that compromised the palpebral closure. No traumatic or surgical history was found. Slit‐lamp examination of the contralateral eye also revealed a degenerative area with corneal thinning. In order to determine the etiology of this lesion, 70 Mhz ultrasound (VevoMD high‐frequency ultrasound system, Fujifilm, Toronto, Canada), anterior segment optical coherence tomography (OCT, Casia 1, Tokyo, Japan) and in vivo confocal microscopy (IVMC, Vivascope 3000, LUCID, NY, USA) were performed. Surgical removal of the lesion consisted of en bloc removal of the cystic lesion followed by limbal conjunctiva and amniotic membrane graft for analgesic purposes and to accelerate wound healing. Histology and direct immunofluorescence were performed. Results 70 Mhz ultrasonography and OCT revealed a single non‐segmented cyst, without scleral fistula or corneal thinning. IVMC showed a single well delineated cyst with clearly visible distinct partitions with no image in favour of malignancy. No signs of malignancy or ocular pemphigoid were founded by histology. We, therefore, concluded to an atypical presentation of Terrien's marginal degeneration. Conclusions The combination of sophisticated imaging like ultra‐high frequency 70 Mhz ultrasound, AS‐OCT and IVCM are necessary for diagnostic and therapeutic management of atypical cornea lesions.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".