The Study of Loss of Mitochondrial Membrane Protein mgr2 Gene Results in Changes of Cell Dynamics in Fission Yeast
Bibliographic record
Abstract
The mgr2 gene encodes an important transmembrane protein in mitochondria, which plays an important role in cell growth and survival. The model of Schizosaccharomyces pombe and the live cell imaging was used to explore the effect of mgr2 gene deletion on cell dynamics in mitosis. The results showed that the deletion of mgr2 gene would cause the number and length of microtubules abnormality and affect microtubule dynamics at interphase. At the same time, spindle microtubule dynamics were different in mgr2 Δ cells compared with wild type cells. Spindle length statistics showed that there was delayed spindle breakage in mgr2 Δ cells. The mgr2 gene deletion can also affect the spindle growth rate in the metaphase，metaphase time and anaphase time. Live-cell imaging were performed on mutant strains to observe two distinct chromosome behaviors: normal and lagging. In addition, there was abnormal spindle breakage. It is concluded that the loss of mgr2 gene from mitochondria caused abnormal cell mitosis, which would contribute to the spindle maintenance deficiency, chromosome segregation deficiency, spindle breakage deficiency.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".