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Record W3127123397 · doi:10.1073/pnas.2010632118

The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS

2021· article· en· W3127123397 on OpenAlexafffund
Joseph D. Orkin, Michael J. Montague, Daniela Tejada-Martínez, Marc de Manuel, Javier del Campo, Saúl Cheves Hernández, Anthony Di Fiore, Claudia Fontsere, Jason A. Hodgson, Mareike C. Janiak, Lukas F. K. Kuderna, Esther Lizano, Maria Pia Martin, Yoshihito Niimura, George H. Perry, Carmen Soto Valverde, Jia Tang, Wesley C. Warren, João Pedro de Magalhães, Shoji Kawamura, Tomàs Marquès‐Bonet, Roman Krawetz, Amanda Melin

Bibliographic record

VenueProceedings of the National Academy of Sciences · 2021
Typearticle
Languageen
FieldPsychology
TopicPrimate Behavior and Ecology
Canadian institutionsAlberta Children's HospitalUniversity of Calgary
FundersAgencia Estatal de InvestigaciónNatural Environment Research CouncilAlberta Children's Hospital Research InstituteCanada Research ChairsDirectorate for Biological SciencesWashington University in St. LouisResearch Councils UKEuropean CommissionComisión Nacional de Investigación Científica y TecnológicaJapan Society for the Promotion of Science LondonCentres de Recerca de CatalunyaSight Research UKJapan Society for the Promotion of ScienceUniversity of LiverpoolBiotechnology and Biological Sciences Research CouncilMethuselah FoundationGeneralitat de Catalunya
KeywordsFlexibility (engineering)Adaptation (eye)Evolutionary biologyBiologyGenomicsLongevityBrain sizeGenomeHominidaeEcologyBiological evolutionNeuroscienceGeneGeneticsMedicine

Abstract

fetched live from OpenAlex

Through high-depth sequencing of DNA derived from blood, various tissues, and feces via fluorescence-activated cell sorting (fecalFACS) to isolate monkey epithelial cells, we compared genomes of capuchin populations from tropical dry forests and lowland rainforests and identified population divergence in genes involved in water balance, kidney function, and metabolism. Through a comparative genomics approach spanning a wide diversity of mammals, we identified genes under positive selection associated with longevity and brain development. Additionally, we provide a technological advancement in the use of noninvasive genomics for studies of free-ranging mammals. Our intra- and interspecific comparative study of capuchin genomics provides insights into processes underlying local adaptation to diverse and physiologically challenging environments, as well as the molecular basis of brain evolution and longevity.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.094
Threshold uncertainty score0.397

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.058
GPT teacher head0.355
Teacher spread0.296 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations57
Published2021
Admission routes2
Has abstractyes

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