Influence of polymorphisms in the vascular endothelial growth factor gene on allograft rejection after kidney transplantation: a meta-analysis
Bibliographic record
Abstract
<ns3:p> <ns3:bold>Background:</ns3:bold> Reported associations of allograft rejection in kidney transplant patients with <ns3:italic>VEGF</ns3:italic> single nucleotide polymorphisms (SNPs) have been inconsistent between studies, which prompted a meta-analysis to obtain more precise estimates. </ns3:p> <ns3:p> <ns3:bold>Methods:</ns3:bold> <ns3:italic/> Using the PICO elements, kidney transplant patients (P) were compared by genotype data between rejectors (I) and non-rejectors (C) in order to determine the risk of allograft rejection (O) attributed to the <ns3:italic>VEGF</ns3:italic> SNPs. Literature search of four databases yielded seven articles. To calculate risks for allograft rejection, four SNPs were examined. Using the allele-genotype model we compared the variant ( <ns3:italic>var</ns3:italic> ) with the wild-type ( <ns3:italic>wt</ns3:italic> ) and heterozygous ( <ns3:italic>var</ns3:italic> - <ns3:italic>wt</ns3:italic> ) alleles. Meta-analysis treatments included outlier and subgroup analyses, the latter was based on ethnicity (Indians/Caucasians) and rejection type (acute/chronic). Multiple comparisons were corrected with the Bonferroni test. </ns3:p> <ns3:p> <ns3:bold>Results:</ns3:bold> Five highly significant outcomes (P <ns3:sup>a</ns3:sup> < 0.01) survived Bonferroni correction, one of which showed reduced risk for the <ns3:italic>var</ns3:italic> allele (OR 0.61, 95% CI 0.45-0.82). The remaining four indicated increased risk for the <ns3:italic>wt</ns3:italic> allele where the chronic rejection (OR 2.10, 95% CI 1.36-3.24) and Indian (OR 1.44, 95% CI 1.13-1.84) subgroups were accorded susceptibility status. </ns3:p> <ns3:p> <ns3:bold>Conclusions:</ns3:bold> Risk associations for renal allograft rejection were increased and reduced on account of the <ns3:italic>wt</ns3:italic> and <ns3:italic>var</ns3:italic> alleles, respectively. These findings could render the <ns3:italic>VEGF</ns3:italic> polymorphisms useful in the clinical genetics of kidney transplantation. </ns3:p>
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.002 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".