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Record W3129852255 · doi:10.1134/s0362119720080101

Internal Carotid Artery Stenting: Predictive Screening of Cognitive Function

2020· article· en· W3129852255 on OpenAlexaboutno aff
Р.Б. Медведев, Э Г Гемджян, В. Л. Щипакин, A. Yu. Koshcheev, Р. Н. Коновалов, M. М. Tanashyan

Bibliographic record

VenueHuman Physiology · 2020
Typearticle
Languageen
FieldMedicine
TopicCerebrovascular and Carotid Artery Diseases
Canadian institutionsnot available
Fundersnot available
KeywordsMedicineInternal carotid arteryMontreal Cognitive AssessmentAngioplastyStenosisRestenosisStroke (engine)Carotid endarterectomyInternal medicineCardiologyCarotid stentingRadiologyAsymptomaticSurgeryStentCognitive impairment

Abstract

fetched live from OpenAlex

Abstract Carotid artery stenting is a common method of stroke prevention. The aim of this work was to examine the relationship between carotid angioplasty with stenting (CAS) of the internal carotid artery (ICA) and cognitive function (CF), based on two years of patient follow-up data (after stenting), including clinical assessment and neuroimaging using magnetic resonance imaging (MRI). This prospective study included 137 patients (64% men) aged 47 to 85 years (with a median age of 66 years), who had undergone CAS for atherosclerotic stenosis. The inclusion criterion was stenosis (symptomatic or asymptomatic) of the internal carotid artery, which was confirmed on ultrasound. The exclusion criteria were patients with stroke (whose neurological deficits included aphasia and/or neglect), severe cognitive and mental disorders, contraindications to antiplatelet drugs and statins, and patients with ICA restenosis after prior carotid endarterectomy. The Montreal Cognitive Assessment (MoCA) Test was used for cognitive function screening before stenting, and 6, 12, and 24 months after the vascular intervention. Diffusion-weighted MRI was used to assess the presence (before CAS and 24 hours after surgery) of focal cerebral changes, specifically intraoperative acute embolic lesions (AEL). Patients with previously identified AEL were re-examined using 3D-FLAIR MRI after 6 months. The number of patients with cognitive impairment, who had scored less than 26 points on the MoCA, was 23/137 (17%) prior to the CAS. When measured 6, 12 and 24 months after stenting, there was no statistically or clinically significant change in cognitive function in 125/137 (91%) patients, cognitive function improved in 12/137 (9%) (3 of whom had reduced CF before stenting), and there were no instances of deterioration. No association was found between asymptomatic foci due to intraoperative AEL, and postoperative cognitive abilities.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.723
Threshold uncertainty score0.494

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.026
GPT teacher head0.259
Teacher spread0.233 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2020
Admission routes1
Has abstractyes

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