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Record W3134851073 · doi:10.1016/s2213-8587(21)00019-x

Anti-interleukin-21 antibody and liraglutide for the preservation of β-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial

2021· article· en· W3134851073 on OpenAlexaff
Matthias von Herrath, Stephen C. Bain, Bruce W. Bode, Jesper O. Clausen, Ken Coppieters, Janusz Gumprecht, Troels Krarup Hansen, Chantal Mathieu, Cristóbal Morales, Ofri Mosenzon, Stine Segel, George Tsoukas, Thomas R. Pieber, Bernhard Ludvik, Rudolf Prager, Bernhard Paulweber, Christoph Ebenbichler, Bart Keymeulen, Christophe De Block, Loren D. Grossman, Robyn L. Houlden, Patrice Perron, Thomas Ransom, Peter Senior, S. John Weisnagel, Vincent Woo, R Dumas, David Thompson, Tina Vilsbøll, Jeppe Gram, Claus Bogh Juhl, Janne Hukkanen, Jorma Lahtela, Leo Niskanen, Donal O’Shea, Timothy O’Brien, Séamus Sreenan, Julio Wainstein, Moshe Phillip, Hilla Knobler, Francesco Dotta, Pier Marco Piatti, Roberto Trevisan, Agostino Gnasso, Hanne L. Gulseth, John Cooper, Ewa Pańkowska, Monika Łukaszewicz, Bogumił Wolnik, Isabel Manita, Olinda Marques, Cristina Roque, Rosa Maria Príncipe, Celestino Neves, Susana Heitor, L. A. Ruyatkina, I. V. Dvoryashina, Gulnar Vagapova, Lidiya Belousova, M. Sergeeva-Kondrachenko, А. Б. Песков, Elena Frolova, Albina Golovach, М. А. Куницына, N Krasnopeeva, Irina Ipatko, Francisco J. Tinahones, Mercedes Rigla, Juan Francisco Merino-Torres, Luis Alberto Gómez, Mercè Fernández, Rafael Simó, Mikael Rydén, Johan Jendle, Karin Filipsson, Björn Eliasson, Iurii Lymar, Liubov Sokolova, Galyna Myshanych, Tetiana Zlova, М.V. Vlasenkо, Petro Kuskalo -, Hamish Courtney, Colin Dayan, Patrick English, Simon Heller, A.B. Johnson, Sunil Nair, Richard David Leslie, Parth Narendran, Nick Oliver, Shenaz Ramtoola, J. H. F. Shaw, Adie Viljoen, Amer Al‐Karadsheh, Jean M. Dostou, Sumana Gangi, Peter A. Gottlieb, Terri Jerkins, Michael Magnotti, Jennifer B. Marks, Samer Nakhle, Gholamreza Bonabi, L. Myers, Richard E. Pratley, William Hagopian, Jeremy Pettus, Bernt Johan von Scholten, Johnna D. Wesley, Frederik Flindt Kreiner

Bibliographic record

VenueThe Lancet Diabetes & Endocrinology · 2021
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicDiabetes and associated disorders
Canadian institutionsMcGill University
FundersNovo Nordisk FondenNovo Nordisk
KeywordsMedicineLiraglutidePlaceboType 2 diabetesDiabetes mellitusInternal medicineAntibodyEndocrinologyImmunologyAlternative medicinePathology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.018

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0040.002
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0030.004
Insufficient payload (model declined to judge)0.0060.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.019
GPT teacher head0.283
Teacher spread0.264 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations178
Published2021
Admission routes1
Has abstractno

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