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Record W3135980692 · doi:10.15173/m.v1i30.1884

Hereditary Breast and Ovarian Cancer

2018· article· en· W3135980692 on OpenAlexaffvenue
David Bobrowski, David L. Hu

Bibliographic record

VenueThe Meducator · 2018
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicBRCA gene mutations in cancer
Canadian institutionsMcMaster University
Fundersnot available
KeywordsMedicineBreast cancerOvarian cancerOncologyGynecologyCancerInternal medicine

Abstract

fetched live from OpenAlex

Genetic testing for breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) mutations in clinical oncology is becoming more widely employed around the world. Testing allows clinicians to determine if unaffected highrisk women carry a BRCA mutation, and if preventive care in the form of prophylactic procedures and/or increased surveillance is advisable. As well, identifying carrier status can aid physicians in tailoring the best treatment for affected women with breast or ovarian cancer. However, studies have shown that the uptake of preventive strategies, particularly risk-reducing surgeries, among unaffected women found to carry a BRCA mutation is influenced by a number of factors. These include cost of genetic testing, cancer-related distress, patient consultation, perceived benefits and risks of invasive surgery, and level of education. To alleviate these emotional and cognitive barriers, clinicians should ensure women carrying a BRCA mutation are well-informed about available treatments and potentially fatal outcomes associated with breast and ovarian cancer.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.253
Threshold uncertainty score0.243

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.283
Teacher spread0.273 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2018
Admission routes2
Has abstractyes

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