Hepatomegaly in Type 1 Diabetes Mellitus: When to Suspect of Glycogenic Hepatopathy?
Bibliographic record
Abstract
Uncontrolled type 1 diabetes mellitus is associated with recognized short- and long-term complications. The authors describe a case of a female adolescent, with history of poorly controlled type 1 diabetes mellitus, who presented with tender hepatomegaly and elevated liver enzymes. Her growth and pubertal development were appropriated for age. After excluding infectious and autoimmune causes of liver disease, a liver biopsy was performed and histology revealed glycogenosis. Glycogenic hepatopathy is characterized by abnormal glycogen accumulation in hepatocytes. It is a reversible condition, with good glycemic control, and is not known to progress to fibrosis. This entity should be distinct from other causes of hepatomegaly and elevated liver enzymes, in diabetic patients, such as nonalcoholic fatty liver disease. Although glycogenic hepatopathy is a major cause of hepatomegaly in type 1 diabetes mellitus, is rare and likely under-recognized, the diagnosis has implications in the management and outcome. J Med Cases. 2013;4(11):726-728 doi: https://doi.org/10.4021/jmc1516w
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".