Évaluation de l’usage des inhibiteurs du SGLT2 au Centre intégré universitaire de santé et de services sociaux de l’Estrie-Centre hospitalier universitaire de Sherbrooke
Bibliographic record
Abstract
Objectif : Decrire les caracteristiques des patients diabetiques de type 2 qui utilisent un inhibiteur du cotransporteur sodium-glucose de type 2 (iSGLT2) et les comparer a celles des non-utilisateurs de cette classe d’antidiabetiques. Methode : Etude retrospective dans laquelle les donnees ont ete collectees a partir des dossiers medicaux des patients diabetiques de type 2 adultes, admis a l’urgence ou hospitalises au Centre integre universitaire de sante et de services sociaux de l’Estrie-Centre hospitalier universitaire de Sherbrooke entre le 1er janvier 2015 et le 17 aout 2018. Les utilisateurs d’un iSGLT2 ont ete paires (ratio 1:1) aux non-utilisateurs selon la meme date d’admission et le meme nombre de classes d’agents antidiabetiques. Resultats : Les caracteristiques de 439 utilisateurs d’un iSGLT2 ont ete comparees a celles d’un meme nombre de sujets diabetiques de type 2, non utilisateurs. Les utilisateurs d’un iSGLT2 avaient un plus jeune âge (62,9 vs 69,4 ans), moins d’hypertension (38,3 % vs 46,0 %) et une meilleure fonction renale (debit de filtration glomerulaire 84,7 mL/min/1,73 m2 vs 73,4 mL/min/1,73 m2) que les non-utilisateurs. La canagliflozine etait l’iSGLT2 le plus souvent prescrit (55,4 %), et la majorite des sujets avaient au moins trois classes d’antidiabetiques. Conclusion : L’usage des iSGLT2 par des patients plus jeunes, ayant moins d’hypertension et d’insuffisance renale, pourrait refleter l’instauration plus recente de ces medicaments dans l’arsenal therapeutique du diabete. Avec la publication croissante de donnees montrant des benefices de protection cardiovasculaire et renale, ces agents sont susceptibles d’etre davantage prescrits en presence de comorbidites. Abstract Objective: To describe the characteristics of type 2 diabetic patients who use a sodium-glucose cotransporter 2 inhibitor (SGLT2i) and to compare them with those non-users of this class of antidiabetics. Method: A retrospective study in which data were collected from the medical records of adult type 2 diabetic patients admitted to the emergency department or hospitalized at the Centre integre universitaire de sante et de services sociaux de l’Estrie - Centre hospitalier universitaire de Sherbrooke between January 1, 2015 and August 17, 2018. The SGLT2i users were matched (1:1 ratio) to non-users according to the same date of admission and the same number of classes of antidiabetics. Results: The characteristics of 439 SGLT2i users were compared with those of the same number of non-user type 2 diabetic patients. The SGLT2i users were younger (62.9 vs. 69.4 years), had less hypertension (38.3% vs. 46.0%) and better renal function (GFR 84.7 ml/min/1.73 m2 vs. 73.4 ml/min/1.73 m2) than the non-users. Canagliflozin was the most frequently prescribed SGLT2i (55.4%), and most of the patients were using at least three classes of antidiabetics. Conclusion: The use of SGLT2i by younger patients with less hypertension and renal impairment may reflect the more recent introduction of these drugs into the therapeutic arsenal for diabetes. With more and more data being published showing cardiovascular and renal protective benefits, these agents are likely to be prescribed more often in the presence of comorbidities.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.006 | 0.016 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.003 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".