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Record W3143844999 · doi:10.1016/j.annonc.2021.03.205

Cabazitaxel versus abiraterone or enzalutamide in poor prognosis metastatic castration-resistant prostate cancer: a multicentre, randomised, open-label, phase II trial

2021· article· en· W3143844999 on OpenAlexafffund
Matti Annala, Simon Fu, Jack V. W. Bacon, Joonatan Sipola, Nayyer Iqbal, Cristiano Ferrario, Michael Ong, Deepa Wadhwa, Sebastién J. Hotte, Gregory Lo, Ben Tran, Lori Wood, Joel Roger Gingerich, Scott North, Carmel Pezaro, Joseph D. Ruether, Srikala S. Sridhar, Heini Kallio, Daniel Khalaf, Amanda Wong, Kevin Beja, Elena Schönlau, Sinja Taavitsainen, Matti Nykter, Gillian Vandekerkhove, Arun Azad, Alexander W. Wyatt, K.N. Chi

Bibliographic record

VenueAnnals of Oncology · 2021
Typearticle
Languageen
FieldMedicine
TopicProstate Cancer Treatment and Research
Canadian institutionsPrincess Margaret Cancer CentreUniversity of AlbertaMcGill UniversityUniversity of OttawaRegional Municipality of DurhamJuravinski Cancer CentreCanada's Michael Smith Genome Sciences CentreJewish General HospitalKelowna General HospitalCancerCare ManitobaOttawa HospitalQueen Elizabeth II Health Sciences CentreUniversity of SaskatchewanLakeridge HealthUniversity of British Columbia
FundersCanadian Institutes of Health ResearchProstate Cancer CanadaTerry Fox Research InstituteMovember FoundationProstate Cancer Foundation
KeywordsCabazitaxelEnzalutamideMedicineAbirateroneProstate cancerOpen labelOncologyDocetaxelInternal medicinePhases of clinical researchClinical trialChemotherapyCancerAndrogen deprivation therapyAndrogen receptor

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.065
Threshold uncertainty score0.744

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.285
GPT teacher head0.508
Teacher spread0.223 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations71
Published2021
Admission routes2
Has abstractno

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