Probable Bexarotene Hepatotoxicity Associated With Transient Serum Antimitochondrial Antibodies
Bibliographic record
Abstract
Bexarotene is a retinoid X receptor agonist approved for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma. In clinical trials, its use has been associated with elevations in serum aminotransferase activities. This report describes a case of probable bexarotene-induced hepatocellular injury in a woman, which was originally misdiagnosed as primary biliary cirrhosis because of the transient presence of serum antimitochondrial antibodies. Liver biopsy showed portal and periportal inflammation, ceroid-laden macrophages and normal bile ducts. Serum aminotransferase activities returned to normal approximately 8 weeks after discontinuing bexarotene and serum antimitochondrial antibodies were not detectable approximately one year after stopping the drug. This case reinforces the need to consider the possibility of drug-induced liver injury in patients taking bexarotene and that serum antimitochondrial antibodies may be transiently detectable in such individuals. J Med Cases. 2012;3(4):226-228 doi: https://doi.org/10.4021/jmc633w
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".