Thin Basement Membrane Disease Associated With Nephrotic Range Proteinuria, Hypertension and Chronic Kidney Disease
Bibliographic record
Abstract
Thin basement membrane disease (TBMD) is typically associated with hematuria but proteinuria is an uncommon presentation. When proteinuria is present, it is mostly in a non-nephrotic range, moreover, when proteinuria is in nephrotic range, generally it is associated with presence of glomerulopathies, Focal Segmental Nephrosclerosis, IgA Nephropathy or minimal change and is rarely present in an isolated TBMD. We present a case of 53-year-old male with history of hypertension for 15 yrs, coronary artery disease, rheumatoid arthritis and stage III chronic kidney disease who was referred to us for evaluation of long-standing chronic microscopic hematuria and new onset nephrotic range proteinuria. Given the fact that the proteinuria was new and in nephrotic range a biopsy was performed and was consistent with TBMD without other glomerlopathies or any other abnormalities seen. Our patient had CKD stage III serum (creatinine1.2 - 1.6 mg/dL), which was a stable finding for past 12 years. Microscopic hematuria was persistent for 24 years with new onset (6 month) of proteinuria. This case of TBMD is unique in terms of new onset nephrotic range proteinuria after long standing hematuria for 24 years. doi: http://dx.doi.org/10.4021/wjnu97w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".