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Record W3153788217 · doi:10.1073/pnas.2013925118

Patterns of bacterial motility in microfluidics-confining environments

2021· article· en· W3153788217 on OpenAlexafffund
Viola Tokárová, Ayyappasamy Sudalaiyadum Perumal, M. M. Nayak, Henry Shum, Ondřej Kašpar, Kavya Rajendran, Mahmood Mohammadi, Charles Tremblay, Eamonn A. Gaffney, Sylvain Martel, Dan V. Nicolau

Bibliographic record

VenueProceedings of the National Academy of Sciences · 2021
Typearticle
Languageen
FieldEngineering
TopicMicrofluidic and Bio-sensing Technologies
Canadian institutionsPolytechnique MontréalUniversity of WaterlooMcGill University
FundersAustralian Research CouncilSocial Sciences and Humanities Research Council of CanadaNatural Sciences and Engineering Research Council of CanadaGrantová Agentura České RepublikyGovernment of CanadaAdvanced Research Projects AgencyDefense Advanced Research Projects AgencyMcGill University
KeywordsMotilityFlagellumMicrofluidicsMesoscale meteorologyNanomechanicsNanotechnologyBiological systemPhysicsBiophysicsBiologyBacteriaMaterials scienceCell biologyAtomic force microscopyMeteorology

Abstract

fetched live from OpenAlex

Significance Understanding bacterial movement is crucial for health, agriculture, environment, and industry. Studying the motility of five bacterial species in microfluidic environments showed that bacterial motility behavior is the result of a “tug-of-war” between hydrodynamics and local nanomechanics. In less confining spaces, bacterial motility is governed by hydrodynamics and can be approximately predicted by modeling developed for the simplest species. Conversely, in tightly confining environments, movement is mainly controlled by the steric interactions between flagella and the surrounding walls. Intriguingly, in mesoscale-sized geometries, hydrodynamics and bacterium–wall interactions overlap, either “constructively,” leading to smooth movement in straight channels, or “destructively,” leading to trapping. Our study provides a methodological template for the development of devices for single-cell genomics, diagnostics, or biocomputation.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.005

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.001
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.029
GPT teacher head0.246
Teacher spread0.217 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations73
Published2021
Admission routes2
Has abstractyes

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Same venueProceedings of the National Academy of SciencesSame topicMicrofluidic and Bio-sensing TechnologiesFrench-language works237,207