MAGNESIUM AND TAURINE, FIRST PROVEN TO BE PREVENTIVE NUTRIENTS IN STROKE-PRONE RAT MODELS WERE 24-H URINARY BIO-MARKERS ASSOCIATED WITH LOWER CV RISKS WORLD-WIDELY, ALSOINJAPANESE AND MEDITERRANEAN POPULATIONS
Bibliographic record
Abstract
Objective: Since stroke was prevented by taurine(T)- and magnesium(Mg)-rich diets even in salt-loaded stroke-prone SHR models, we examined the association of 24-hour urinary(24U) T and Mg/creatinine (C) ratios with cardiovascular risks (CVR) world-wide and studied these biomarkers in Japanese and Mediterranean populations (J, M) in comparison with Euro-Western populations(EW). Design: The association of 24U T and Mg/C with CVR was cross-sectionally analyzed among 4211 participants, 49.7% females(F), aged 48–56 years in 50 populations from 22 countries according to the WHO-CARDIAC study protocol and further analyzed comparatively in 6 J (864, 53.8%F), 6 M(574, 50.2%,F from Greece, Sicily, Italy, Spain, Portugal) and 6 EW(549,45.9% F from Sweden,Ireland, Scotland, Canada, Australia,New Zealand). Design and method: In a world-wide linier regression analysis, T/C and Mg/C were inversely associated with BMI, systolic and diastolic blood pressure (SBP, DBP) and serum total cholesterol (TC) significantly (P for linear trend <0.001, respectively). The prevalence of obesity, hypertension and hypercholesterolemia among the subjects of the lowest quintile of T/C (Mg/C) was 2.84 (2.49), 1.22 (1.49) and 2.20 (2.39) times higher (P < 0.05 or <0.001) than those in the subjects of the highest quintile. In a comparison of J and M (both males and females) with EW, 24U T and Mg/C in both populations were significantly higher than in EW, and SBP, DBP, TC and non-HDL cholesterol were significantly lower in J and M, despite their significantly higher 24U salt, than in EW, indicating that these biomarkers could contribute to lower coronary heart disease mortality, benefiting longevity in J and M. Conclusion: T and Mg are regarded as beneficial dietary factors for reducing CVR world-wide and are related with the merits of J and M diets compared with EW diets despite the higher salt intake, indicating that low salted T- and Mg-rich dietary intakes are recommendable for promoting CVR reduction.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".