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Record W3157585265

Blood Group ABO-incompatible Kidney Transplantation

2021· article· en· W3157585265 on OpenAlex
Annelies de Weerd

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

aboutThe title or abstract carries a Canadian signal from the geographic lexicon.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueEUR Research Repository (Erasmus University Rotterdam) · 2021
Typearticle
Languageen
FieldMedicine
TopicRenal Transplantation Outcomes and Treatments
Canadian institutionsnot available
Fundersnot available
KeywordsABO blood group systemKidney transplantationTransplantationDesensitization (medicine)MedicineKidneyInternal medicineReceptor
DOInot available

Abstract

fetched live from OpenAlex

BackgroundABO blood group-incompatible kidney transplantation is considered a safe procedure, with non-inferior outcomes in large cohort studies.Its contribution to living kidney transplantation programs is substantial and growing.Outcomes compared to centermatched ABO blood group-compatible control patients have not been ascertained. DesignComprehensive searches were conducted in Embase, Medline, Cochrane, Web-of-Science and Google Scholar.MOOSE study guidelines for observational studies and Newcastle Ottawa bias scale were implemented to assess studies.Meta-analysis was performed using Review Manager 5.3.A subgroup analysis on antibody removal technique was performed. ResultsAfter identifying 2728 studies addressing ABO-incompatible kidney transplantation, 26 studies were included, describing 1346 unique ABO-incompatible patients and 4943 ABO-compatible controls.Risk of bias was low (all studies ≥ 7/9 stars).Baseline patient characteristics revealed no significant differences in immunological risk parameters.Statistical heterogeneity of studies was low (I 2 0% for graft and patient survival).Oneyear uncensored graft survival of ABO-incompatible patients was 96% versus 98% in ABO-compatible controls (RR 0.97, CI 0.96-0.98,p<0.001).49% of reported causes of death in ABO-incompatible patients were of infectious origin, versus only 13% in ABOcompatible patients (p=0.02).Antibody-mediated rejection (3.86, CI 2.05-7.29,p<0.001), severe non-viral infection (1.44, p=0.003) and bleeding (1.92, p<0.001) were also more common after ABO-incompatible transplantation. ConclusionABO-incompatible kidney transplant recipients have good outcomes albeit inferior to center-matched ABO-compatible control patients.20 Chapter 2 26 Chapter 2 Table 1 (continued).Overview of the included studies in the meta-analysis.Study period country ABOi ABOc controls desensitization induction follow-up (months) Iwai, 2015 (34)

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.129
Threshold uncertainty score0.769

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.036
GPT teacher head0.305
Teacher spread0.270 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it