SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Full frame distilled prediction
Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
- Candidate categories
- none
- Consensus categories
- none
- Domain
- Candidate signal: noneConsensus signal: none
- Study design
- Candidate signal: Not applicableConsensus signal: none
- Genre
- Candidate signal: ReviewConsensus signal: Review
- Teacher disagreement score
- 0.767
- Threshold uncertainty score
- 0.670
- Validation status
machine_predicted_unvalidated·codex-gemma-dda1882f352a
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.329 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
Multisystem inflammatory syndrome in children (MIS-C) emerged in April 2020 in communities with high COVID-19 rates. This new condition is heterogenous but resembles Kawasaki disease (KD), a well-known but poorly understood and clinically heterogenous pediatric inflammatory condition for which weak associations have been found with a myriad of viral illnesses. Epidemiological data clearly indicate that SARS-CoV-2 is the trigger for MIS-C, which typically occurs about 1 mo after infection. These findings support the hypothesis of viral triggers for the various forms of classic KD. We further suggest that rare inborn errors of immunity (IEIs) altering the immune response to SARS-CoV-2 may underlie the pathogenesis of MIS-C in some children. The discovery of monogenic IEIs underlying MIS-C would shed light on its pathogenesis, paving the way for a new genetic approach to classic KD, revisited as a heterogeneous collection of IEIs to viruses.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- The Journal of Experimental Medicine
- Topic
- Kawasaki Disease and Coronary Complications
- Field
- Medicine
- Canadian institutions
- BC Children's HospitalUniversity of British Columbia
- Funders
- National Human Genome Research InstituteNIHR Imperial Biomedical Research CentreInstituto de Salud Carlos IIINational Institutes of HealthSCOR Corporate Foundation for ScienceNational Health and Medical Research CouncilNovo Nordisk FondenFondation pour la Recherche MédicaleAgencia Estatal de InvestigaciónYale UniversityUniversity of New South WalesNational Institute of Allergy and Infectious DiseasesAgence Nationale de la RechercheUniversité de ParisImperial College Healthcare NHS TrustImperial College LondonRockefeller UniversityUK Research and InnovationMinisterio de Ciencia e InnovaciónNational Institute for Health and Care ResearchInstitut National de la Santé et de la Recherche MédicaleBurroughs Wellcome FundFondation du SouffleAmerican Academy of Allergy Asthma and ImmunologyMichael Smith Health Research BCSt. Giles FoundationNational Center for Advancing Translational SciencesMedical Research CouncilHoward Hughes Medical Institute
- Keywords
- Kawasaki diseasePathogenesisDiseaseImmunologyImmune systemImmunityCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)BiologyViral pathogenesisViral infectionVirologyMedicineVirusInfectious disease (medical specialty)Viral replicationPathology
- Has abstract in OpenAlex
- yes