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Record W3158704474 · doi:10.1128/msphere.00011-21

Temporal Dynamics and Evolution of SARS-CoV-2 Demonstrate the Necessity of Ongoing Viral Genome Sequencing in Ontario, Canada

2021· article· en· W3158704474 on OpenAlex
Calvin Sjaarda, Jennifer L. Guthrie, Samira Mubareka, Jared T. Simpson, Bettina Hamelin, Henry Wong, Leanne Mortimer, Robert Slinger, Andrew G. McArthur, Marc Desjardins, Allison McGeer, Tony Mazzulli, Katya Douchant, Danielle Brabant-Kirwan, Ramzi Fattouh, Aaron Campigotto, Samir N. Patel, Nahuel Fittipaldi, Robert I. Colautti, Prameet M. Sheth

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.
aboutThe title or abstract carries a Canadian signal from the geographic lexicon.

Bibliographic record

VenuemSphere · 2021
Typearticle
Languageen
FieldMedicine
TopicSARS-CoV-2 and COVID-19 Research
Canadian institutionsHospital for Sick ChildrenHealth Sciences NorthUniversity Health NetworkMount Sinai HospitalKingston Health Sciences CentreUniversity of OttawaQueen's UniversityOntario GenomicsAgricultural Research Institute of OntarioSunnybrook Health Science CentrePublic Health OntarioOntario Institute for Cancer ResearchUniversity of TorontoMcMaster University
FundersDalhousie UniversitySunnybrook Research InstituteMcMaster University
KeywordsGenomeBiologyTransmission (telecommunications)Mutation rateSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Evolutionary biologyGeneticsMutationPopulationGenetic variationCoronavirusTransmission rateVirologyDiseaseInfectious disease (medical specialty)GeneMedicine

Abstract

fetched live from OpenAlex

) for SARS-CoV-2 is typical for coronaviruses. Analysis of published SARS-CoV-2 genomes revealed that the G614 spike protein mutation has dominated infections in Ontario and that SARS-CoV-2 lineages present in Ontario have not differed significantly in their rate of spread. These results suggest that the SARS-CoV-2 population circulating in Ontario has not changed significantly to date. However, ongoing genome monitoring is essential for identification of new variants and lineages that may contribute to increased viral transmission.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.021
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.030
GPT teacher head0.284
Teacher spread0.253 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it