Short Term Clinical Results of Single Injection Autologous BMAC (Bone Marrow Aspirate Concentrate) As A Therapeutic Option/Tool in Knee Osteoarthritis
Bibliographic record
Abstract
Abstract Background: Knee Osteoarthritis (KOA) is a common degenerative joint disease characterized by loss of articular cartilage, osteophyte formation, resulting in disability and affecting the quality of life. There is no treatment as on today to reverse the progression of KOA. The present available treatments for KOA are palliative. Therefore, there is a need for an alternative treatment modality in the treatment of KOA during the early grades, which should help in not only giving a symptomatic relief but also downturn the disease process. Bone marrow aspirate concentrate (BMAC) has gained a considerable importance change in the management/treatment of KOA in the recent times due to its potential advantages of disease modifying and regeneration capacities. The latest studies on usage of Autologous BMAC injection in KOA showed promising and encouraging results in terms of decrease in the pain, improved knee range of movement, daily activities of living and thus improved expectations for good quality lives. The current study aimed to assess the role of single injection- autologous BMAC as a therapeutic option in the treatment of KOA and evaluate the functional and clinical outcome of KL grade II&III patients.Methods: One Hundred and thirty-two patients with KOA (KL grade II&III) were included in the study as per the inclusion criteria. Autologous Bone marrow aspiration was done and the separation was done using density gradient centrifugation and final aspirate was injected into the knee joint. Results: The clinical outcomes of the patients were evaluated at different time points both objectively [Visual Analogue Scale (VAS) & WOMAC (Western Ontario Mac Master Universities Score)] and subjectively (radiographs & MRI) and the follow up was done for a period of one year. At the end of the study period, BMAC therapy showed promising results with encouraging clinical outcome.Conclusion:BMAC therapy has more potential with satisfactory, efficient and durable results in KOA. BMAC/mononuclear cells with enriched stem cell therapy can be an alternative therapy as an early intervention option for knee osteoarthritis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".