Abstract 15776: Outcomes of Atrioventricular Septal Defects in Patients With and Without Trisomy 21: Analysis of the Inpatient Sample Database
Bibliographic record
Abstract
Introduction: Atrioventricular septal defect (AVSD) is among the most common congenital heart diseases especially in infants with trisomy 21 (T21). However, the clinical outcomes of AVSD are largely limited to institutional reports. Aim: Using U.S.A. national database, the purpose of this study was to a) to assess the prevalence, mortality and outcomes of AVSD, and b) to determine the impact of T21 on its outcomes. Methods: We queried The US National Inpatient Sample from the Healthcare Cost and Utilization Project for patients with AVSD with and without T21 in the period 2002-2017. Patient characteristics, comorbidities, mortality, and healthcare utilization were evaluated for AVSD comparing those with and without T21. Results: During the study period, a total of 20,628,538 infants were born in the in the US, of them 67,020 (0.3%) had AVSD. T21 was diagnosed in 34,825 (52%). The incidence of AVSD ranged from 4.5-7.4/year. Common associated CHD were transposition of great arteries, tetralogy of Fallot, and truncus arteriosus at 10.9%, 4%, 0.4% respectively. The association with CHD was not different between AVSD with and without T21. During study period, 92% of patients underwent surgical repair. AVSD patients with T21 had greater mortality (4.4% vs 1.1%, p<0.001) more frequent pulmonary hypertension (4.8% vs 2.7%, p<0.001), longer median length of hospital stay (7 vs 3 days), and less incidence of arrhythmia (2.8% vs 6%, p<0.001). Comparisons between AVSD with and without T21 are outlined in table 1. Conclusion: Almost half of infants with AVSD had T21. T21 is associated with greater mortality and pulmonary hypertension, longer hospitalization and less arrhythmia.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.005 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".