Two Imported Cases of New Variant COVID-19 First Emerging from Brazil — Guangdong Province, China, April 30, 2021
Bibliographic record
Abstract
On April 15, 2021, a 62-year-old male (Patient A, XG4122) and a 58-year-old female (Patient B, XG4123) travelled from Canada via airplane and were transferred to a central isolation hotel after being tested by the laboratory of Guangzhou Customs using nose swab tests for coronavirus disease 2019 (COVID-19).The results for both patients returned COVID-19 positive and the couple were transported to the Guangzhou Eighth People's Hospital for isolated treatment by ambulance on April 16, 2021.Patient A had inflamed lungs while Patient B had mild inflammation in her lungs according to the chest computed tomography (CT) examination.Both of their 28 close contacts underwent centralized isolation and medical observation.On April 21, 2021, Guangdong Provincial CDC received the samples and began virus isolation and gene sequencing analysis.On April 27, 2021, the 2 samples were sequenced using Nanopore GridION.On April 30, 2021, the sequencing analysis concluded that the 2 virus genomes belonged to lineage P.1, 20J/501Y.V3, which was first found in four Brazilians after a routine check at Japan's Haneda Airport in late December 2020.The variant was then widely spread to Manaus in the northern State of Amazona in Brazil.The Brazil variant has been reported in 40 different countries as of April 30, 2021(1).Compared with the Wuhan reference sequence (EPI_ISL_402119) (2-3), the strain from Patient A (XG4122) displayed 33 nucleotide variation sites (C241T, T733C, C2749T, C3037T, C3828T, A5648C, A6319G, A6613G, G9105A, C12778T, C14408T
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".