The role of single nucleotide polymorphisms of IL-1A -889C>T (rs1800587), TNF-A -238G>A (rs361525), and VDR TaqI (rs731236) on susceptibility to herniated nucleus pulposus
Bibliographic record
Abstract
<ns4:p> <ns4:bold>Background</ns4:bold> : The objective of this study was to determine the role of single nucleotide polymorphisms (SNPs) in interleukin 1 alpha ( <ns4:italic>IL-1A</ns4:italic> ), tumor necrosis factor-alpha ( <ns4:italic>TNF-A</ns4:italic> ), and vitamin D receptor ( <ns4:italic>VDR</ns4:italic> ) genes on the susceptibility to herniated nucleus pulposus (HNP). </ns4:p> <ns4:p> <ns4:bold>Methods</ns4:bold> : Four databases (PubMed, Embase, Cochrane, and Web of Science) were searched as of April 1 <ns4:sup>st</ns4:sup> , 2021. Authors, publication year, targeted genes, genotype and allele frequency in each case and control groups were collected. Newcastle-Ottawa scale was used to evaluate the publication quality. The pooled estimates of association of <ns4:italic>IL-1A</ns4:italic> -889C>T (rs1800587), <ns4:italic>TNF-A</ns4:italic> -238G>A (rs361525), and <ns4:italic>VDR TaqI</ns4:italic> (rs731236) and susceptibility to HNP were assessed using Z test and presented as odd ratio (OR) and 95% confidence intervals (95%CI). </ns4:p> <ns4:p> <ns4:bold>Results</ns4:bold> : We screened 3,067 unique studies for eligibility and three, two and nine studies on <ns4:italic>IL-1A</ns4:italic> -889C>T, <ns4:italic>TNF-A</ns4:italic> -238G>A, and <ns4:italic>VDR TaqI</ns4:italic> were included, respectively, in our meta-analysis. The studies consisting 369 HNP cases and 433 controls for <ns4:italic>IL-1A</ns4:italic> -889C>T, 252 cases and 259 controls for <ns4:italic>TNF-A</ns4:italic> -238G>A and 1130 cases and 2096 controls for <ns4:italic>VDR TaqI.</ns4:italic> Our pooled estimates indicated that there was no significant association of those SNPs with the susceptibility to HNP in any genotype, dominant model, recessive model, or allele comparations. </ns4:p> <ns4:p> <ns4:bold>Conclusion</ns4:bold> : Although individual studies suggested the important role of gene expression dysregulation associated with SNPs in <ns4:italic>IL-1A</ns4:italic> , <ns4:italic>TNF-A</ns4:italic> , and <ns4:italic>VDR</ns4:italic> , our data indicated that <ns4:italic>IL-1A</ns4:italic> -889C>T, <ns4:italic>TNF-A</ns4:italic> -238G>A, and <ns4:italic>VDR TaqI</ns4:italic> had weak association with HNP susceptibility in both genotypes and allele distributions. However, since heterogeneity was identified among studies included in this meta-analysis, further meta-analysis with a larger population and subgroup analysis on specific population are warranted to support this finding. </ns4:p>
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.013 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.002 | 0.005 |
| Research integrity | 0.001 | 0.005 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".