Bioaccumulation of dodecamethylcyclohexasiloxane (D6) in fish
Bibliographic record
Abstract
To investigate the bioaccumulation behavior of dodecamethylcyclohexasiloxane (D6, CAS number: 540-97-6) in fish, an OECD-305 style dietary bioaccumulation study of D6 in rainbow trout was conducted in the presence of non-metabolizable reference chemicals. The dietary uptake absorption efficiency of D6 was 14 (3 SE) % and lower than that of the reference chemicals which ranged between 22 (2 SE) to 60 (8 SE) %. The concentration of D6 in the body of the fish showed a rapid 40% drop during the first day of the depuration phase, followed by a slower decline during the remainder of the depuration period. The overall depuration rate constant of D6 was 0.016 (0.0026 SE) d−1 and significantly greater than those of PCB153 and PCB209, which were not significantly different from zero. During the depuration phase, when fish body weight did not significantly change over time, depuration of D6 appears to be almost entirely due to biotransformation in the body of the fish. The biomagnification factor of D6 in rainbow trout was 0.38 (0.14 SE) kg-lipid kg-lipid−1, indicating a lack of biomagnification. The bioconcentration factor (BCF) of D6 in Rainbow trout was estimated at 1909 (483 SE) L kg−1 wet for natural waters of mostly oligotrophic lakes in Northern Canada with an average concentration of total organic carbon of 7.1 mg L−1. Comparing the bioaccumulation profile of D6 to that of 238 similar profiles for 166 unique chemicals indicates that the bioaccumulation capacity of D6 is markedly less than that of many very hydrophobic organochlorines.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".