STRUCTURE ‐ FUNCTION ANALYSIS OF THE LIGAND BINDING POCKET OF BITTER TASTE RECEPTOR T2R4
Bibliographic record
Abstract
Bitter taste receptors (T2Rs) belong to the G protein coupled receptors super family. The 25 human T2Rs are activated by wide range of bitter compounds which includes alkaloids, terpenoids, peptides and amines. The human T2R4 is activated by around 16 bitter agonists, which are mostly sesquiterpene lactones, amine derivatives, purine analogs and aromatic quinolines. From molecular modeling analysis we found that, the plant hormone abscisic acid (ABA), an ABA biosynthetic precursor and few of the ABA metabolites docked with high affinity to T2R4. The ability of these compounds to activate or inactivate T2R4 was analyzed by calcium imaging in a HEK293 cell based assay system. We discuss the results in the context of T2R4 structure and function.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".