The effect of two doses of vitamin D3 (400 IU vs. 2000 IU/d) on serum 25‐hydroxyvitamin D in children with Crohn's disease
Bibliographic record
Abstract
Vitamin D is crucial for Crohn's disease (CD) patients to maximize bone mineral density and because vitamin D insufficiency has been linked to increased disease activity. We tested whether 2000 IU/d ( vs . 400 IU/d) of vitamin D 3 yields a higher proportion of children with CD with serum 25‐hydroxyvitamin D (25OHD) concentration ≥ 50 or ≥ 75 nmol/L. 83 patients (8–18 yr) with quiescent CD (Pediatric Crohn's Disease Activity Index (PCDAI) ≤ 10) were randomized to either 400 or 2000 IU/d for 6 months. Clinical and biochemical data were collected at baseline, 3 months and 6 months. Using an intention to treat analysis, at 6 months subjects receiving 2000 IU ( vs . 400 IU) were more likely to achieve 25OHD ≥ 75 nmol/L (75% vs. 34%; χ 2 =13, P<0.001), but proportions ≥ 50 nmol/L did not differ (94% vs. 91%). After adjustment for baseline 25OHD, mean (95% CI) serum 25OHD was higher in the 2000 IU group than the 400 IU group, 90 (84–96) vs. 67 (60–73) nmol/L (p<0.001), respectively. Disease activity assessed by the PCDAI, and serum bone specific alkaline phosphatase concentrations, were similar between groups. Vitamin D supplementation of 2000 IU/d allows most children with quiescent CD to reach serum 25OHD concentrations of ≥ 75 nmol/L, while 400 IU/d is associated with concentrations ≥ 50 nmol/L. Funding: University of British Columbia Vitamin Research Fund
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.004 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.002 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".