Clinical effects of mepolizumab in patients with severe eosinophilic asthma according to background therapy: A meta-analysis
Bibliographic record
Abstract
Mepolizumab is an IL-5 antagonist mAb indicated for add-on maintenance treatment for patients with severe eosinophilic asthma and refractory eosinophilic granulomatosis with polyangiitis.1 The Steroid Reduction with Mepolizumab Study (SIRIUS) trial (NCT01691508) demonstrated that mepolizumab reduced the maintenance oral corticosteroid (OCS) dose required for OCS-dependent patients with severe eosinophilic asthma, as well as the exacerbation rate.2 Other phase 2 and 3 trials including Mepolizumab as Adjunctive Therapy in Patients with Severe Asthma (MENSA) (NCT01691521), Mepolizumab Adjunctive Therapy in Subjects with Severe Eosinophilic Asthma on Markers of Asthma Control (MUSCA) (NCT02281318), and Dose Ranging Efficacy and Safety with Mepolizumab in Severe Asthma (DREAM) (NCT01000506) showed that mepolizumab plus standard of care therapy reduced exacerbations in patients with severe eosinophilic asthma.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.010 | 0.018 |
| Meta-epidemiology (narrow) | 0.003 | 0.001 |
| Meta-epidemiology (broad) | 0.013 | 0.047 |
| Bibliometrics | 0.003 | 0.004 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.003 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.003 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".