Chemical group characterization and determination of pharmacological activities of Pandanus fascicularis L. fruit
Why this work is in the frame
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Bibliographic record
Abstract
The present study was designed to investigate analgesic, anti-pyretic, anti-inflammatory, GI motility and cytotoxic activities of fruit extract of P.fascicularis L. The analgesic effect was evaluated by using the acetic acid-induced writhing test. Antipyretic study was done by yeast induced pyrexia. The cytotoxic activity was evaluated by using brine shrimp lethality bioassay. The extracts are used for anti-inflammatory studies by albumin induced edema over a period of time. GI motility test was performed using charcoal. The methanolic, ethanolic and chloroform extracts show presence of maximum phytochemicals such as alkaloid, tannin, saponin, steroid, terpenoid, protein, flavonoid etc. The dose of 400mg/kg is capable of inhibiting 62.96% writhing in comparison to standard Diclofenac sodium. The initial and final rectal temperatures treated with chloroform extract (400 mg/kg) were 38.7±0.45ºC and 37.83±0.37ºC; where the values for Acetyl salicylic acid (100mg/kg) were 38.4±0.11ºC and 37.5±0.010ºC respectively. During cytotoxic bioassay LC50 value was found 1.0636 mg/ml. Oedema reduced from 0.62 ± 0.06 to 0.45 ± 0.02 after 5hr administering of chloroform extract (400 mg/kg), where aspirin did this from 0.60±.002 to 0.42±0.01 at 200mg/kg. The motility rates of castor oil and chloroform extract were 53.24%& 31.78% at 10 ml/kg and 400 mg/kg respectively, where the control showed 63.68% motility rate. These results show that, chloroform extract of fruit of P.fascicularis L. has significant analgesic, anti-pyretic, cytotoxic, anti-inflammatory and GI motility effects that increase with the increase of concentration. It can be assumed that, phytochemicals present, are the source of potency of the chloroform extract.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it