Significant increase in plasma osteocalcin in response to isoflurane induced anaesthesia in guinea pigs
Bibliographic record
Abstract
The effect of the inhaled anaesthetic, isoflurane was studied on osteocalcin (OC) and total deoxypyridinoline (tDPD) in pigmented guinea pigs. Ten female guinea pigs were anaesthetized at five and nine weeks of age with isoflurane. The duration of anaesthesia was similar (20–25 min) in all guinea pigs across both age. Blood samples were collected at both time points, before and after the induction of the anaesthesia. Osteocalcin and tDPD were measured using ELISA (Quidel Corp.). Osteocalcin concentration increased due to isoflurane from 30.1±4.9 to 57.9±11.2 nmol/L (p<0.001) and from 29.1±7.5 to 62.9±15.9 nmol/L (p<0.001), at five and nine weeks of age, respectively. The effect of isoflurane on tDPD was inconsistent for the fifth and ninth week of age. Isoflurane increased tDPD (8.6±1.9 to 10.3±3.0 nmol/L) at five week of age while it decreased it (12.3±4.0 to 10.5±1.7 nmol/L) at nine week of age. The results demonstrate that administration of isoflurane changes both OC and tDPD. Therefore the interpretation of results obtained from animals anaesthetised by isoflurane on bone biomarkers should be made with caution since they may be highlighted or masked by the effect of the anaesthetic. Measurements prior to anaesthesia are recommended for better consistency and comparability in research. This study was funded by CIHR.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".