Implication of nuclear progesterone receptor on respiratory control in newborn mice.
Bibliographic record
Abstract
We tested the hypothesis that nuclear progesterone receptors (PR) contribute to respiratory control development by studying newborn mice lacking PR expression (PRKO) or wild type controls (WT) at 1 and 4 postnatal days (P1 – P4). Minute ventilation was assessed under normoxia and in response to hypoxia (FiO2=14%, 12%, 10%, 20 min each) using whole body plethysmography. Hypoxic ventilatory response (HVR) was expressed as percentage changes from normoxia, apnea frequency was evaluated under normoxia. In P1 and P4 PRKO mice HVR was 2–3 times lower than in WT for the whole range of FiO2, during the early (peak response) and late (steady state) phase of HVR. In P1, the frequency of spontaneous apnea was lower in PRKO than in WT, while the frequency of post‐sigh apnea frequency was similar. In P4, the frequency of spontaneous and post‐sigh apnea was higher in PRKO than in WT. We conclude that the nuclear progesterone receptor plays a prominent role in respiratory regulation in newborn mice. Both phases of HVR (early and late) are disrupted in PRKO mice, likely indicating effects on peripheral chemoreceptors and central integration. Supported by CIHR.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".