Internephron synchronization is modulated by nitric oxide (NO) but not increased renal perfusion pressure (RPP) or reduced renal vascular conductance
Bibliographic record
Abstract
Renal autoregulation is synchronized among nearby nephrons. Synchronization comes from vasomotion conducted upstream through endothelial gap junctions. NO modulates autoregulation and the conductance of arteriolar gap junctions. We tested the role of NO in the regulation of the radius and strength of internephron synchronization. Male Long‐Evans rats ( N =14) were anaesthetized (isoflurane) and their left kidneys were exposed. Cortical perfusion during control and NOS inhibition (L‐NAME, 10mg/kg i.v.) was monitored by laser speckle perfusion imaging. Clusters of synchronized nephrons were identified based on phase coherence in the myogenic and tubuloglomerular feedback operating frequencies. L‐NAME increased blood pressure and decreased renal vascular conductance. After L‐NAME clusters were smaller and more strongly synchronized. When phenylephrine (PE) was used to increase blood pressure, the number of clusters did not change from control. PE infused directly into the kidney reduced renal vascular conductance but the number of clusters and the synchronization strength also did not change. The radius of spontaneous clusters was 2.3mm (myogenic) and 1.8mm (TGF). We conclude that NO modulates internephron synchronization and that this modulation is mediated by either the effect of NO on blood flow dynamics or the effect of NO to reduce gap junction conductance. Supported by CIHR MOP‐102694.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".