Minimal effect of lifetime low phylloquinone intake on bone status in aged rats
Bibliographic record
Abstract
The specific action of vitamin K in bone, whether in the form of phylloquinone (K1) or menaquinone‐4, remains elusive. While there has been reports pointing to beneficial effects of VK in bone health, others have not confirmed such contribution. Furthermore, most research has focussed on the higher ranges of intakes, the potentially detrimental effect of low VK intakes having been neglected. To gain insight on this issue, we conducted a study in which bone status was investigated in 22‐month female SD rats which had been fed diets containing either very low (VL: 80; n=10), low (L: 500; n=8) or moderately high (H: 2000; n=15) levels of K1 (μg/Kg diet) since weaning. A fourth group (n=9) were fed the VL diet until the age of 14 months and the H diet until sacrifice (VL‐H). Measurements, included: area, weight, bone mineral content (BMC), and density (BMD) of whole body, tibiae and femurs; anthropometrics, BMC, BMD and biomechanical testing (Young's modulus, yield and maximum load) of excised femurs. Total body area (p=0.034) and weight (p=0.05) were higher in the VL‐H than in the L group. With respect to bone status, only the BMC of the tibiae were affected by diet, values being higher in the VL‐H than in the VL group (0.374 vs 0.329 mg; p=0.004). All other bone composition or biomechanical measures were unaffected by diet. In this model of normal aging, lifetime low K1 intake had minimal impact on bone status in old age. Supported by CIHR.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".