Age‐dependent cardiovascular responses to severe haemorrhage in conscious lambs
Bibliographic record
Abstract
The present study was designed to investigate cardiovascular responses to severe haemorrhage (exceeding the critical point at which compensatory mechanisms fail) in two age groups of conscious lambs (Group I: 1‐2 weeks, N=5; group II: 6‐7 weeks, N=6). Mean arterial pressure (MAP), systolic and diastolic pressures (SAP, DAP), heart rate (HR) and renal blood flow (RBF) were measured for 20 min before (Control, C) and after a fixed haemorrhage of 30% of calculated blood volume. After haemorrhage in group I lambs, MAP decreased from 75±5 [SD] (C) to 55±8 mmHg at 5 min, returning to 61±6 mmHg at 20 min, while in group II lambs, MAP decreased further from 74±4 (C) to 38±7 mmHg at 5 min, returning to 55±6 mmHg at 20 min. The fall in SAP 5 min after haemorrhage was also greater in group II lambs (104±8 (C) to 65±15 mmHg) than in group I lambs (110±14 (C) to 91±8 mmHg), whereas DAP followed changes in MAP in both groups. HR increased in group I lambs from 164±43 (C) to 193±45 at 5 min, decreasing thereafter, whereas in group II lambs, HR was unaltered from 119±20 (C). After haemorrhage, RBF fell to zero at 5 min in both groups, returning towards C at 20 min. These results provide new evidence that the cardiovascular responses to severe haemorrhage are developmentally regulated. Mechanisms underlying these differential responses are not yet known. This research was supported by the Canadian Institutes of Health Research (CIHR).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".