INCREASING LEPTIN SENSITIVITY VIA PTP1B DELETION DOES NOT INCREASE BLOOD PRESSURE THROUGH AN INCREASED SYMPATHETIC TONE IN MICE ON A BALB/C BACKGROUND
Bibliographic record
Abstract
Protein tyrosine phosphatase 1B (PTP1B) is a molecular brake on the leptin signaling pathway. Deletion of PTP1B increases leptin sensitivity and triggers hypertension in mice on a Balb/C background but not on a C57Bl/6 background. While leptin increases sympathetic tone (ST), whether PTP1B deletion differently increases ST in Balb/C and C57Bl/6 mice remains to be determined. To test the hypothesis that PTP1B deletion increases sympathetic tone in mice on the Balb/C background only, male and female wild‐type (WT) and knockout (KO) mice from both backgrounds were instrumented with jugular and carotid catheters to measure mean arterial pressure response to ganglionic blockade (mecamylamine) and adrenergic stimulation (phenylephrine). On the Balb/C background, PTP1B deletion increases sympathetic tone and reduces vascular adrenergic tone in both male (WT: −39±3% vs KO: −43±4%) and female mice (WT: −34±5% vs KO: − 35±4%). PTP1B deletion similarly increased ST in KO mice on the C57Bl/6 background (WT: 76±8% vs KO: 129±41%) but did not affect their adrenergic tone. Furthermore, in WT animals, sympathetic tone was higher in C57Bl/6 compared to Balb/c mice. Together these data suggest that the hypertension observed in PTP1B KO mice on the Balb/c background cannot be explained by an enhanced sympathetic tone.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.003 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".