Anthropometry, Energy Metabolism and Nutritional Intake of Girls with Adolescent Idiopathic Scoliosis
Bibliographic record
Abstract
Purpose of the study Adolescent idiopathic scoliosis (AIS) is a tridimensional spine deformation of unknown cause that affects 2–3% of children and mostly girls. Studies have suggested that girls with AIS are taller and leaner than controls, but more studies are needed to confirm these results. While differences in energy metabolism and nutritional intake could explain these discrepancies, they have been poorly studied in AIS. This study aims to thoroughly characterize the anthropometric, metabolic and nutritional profiles of girls affected by AIS and to compare them to age‐matched healthy controls. Methods 20 girls with AIS and 20 healthy controls are being enrolled. Anthropometric parameters (weight, standing and sitting height, body mass index (BMI), waist circumference and arm spam) are measured. Fasting glucose, insulin and lipid profile (total cholesterol, LDL‐cholesterol, HDL‐cholesterol, triglycerides and apolipoprotein B) are assessed. Bone mineral density and body composition are determined by osteodensitometry scan and questionnaires are administered to assess food intake and physical activity level. Results To this day, 17 AIS (14.9 ± 1.9 yrs, mean Cobb angle of 27.2 ± 10.0°) and 12 healthy girls (15.2 ± 1.6 yrs) have completed the study. Compared to controls, we observed in AIS girls tendencies for lower BMI (BMI‐for‐age z‐score: −0.50 ± 0.90 vs. 0.09 ± 1.20, P=0.3669), fat percentage (−15%, P=0.1213), waist circumference (−7%, P=0.0706) and bone mineral density (−8%, P=0.0217). There was no difference in fasting glucose (4.98 ± 0.27 vs. 4.84 ± 0.27 mmol/L, P=0.1852) and insulin (52.46 ± 19.87 vs. 54.12 ± 19.41 ρmol/L, P=0.8365) between groups. A tendency for a perturbed lipid profile was also found in AIS girls with higher triglycerides (18%, P=0.2866), LDL‐cholesterol (16.5 %, P=0.0306), apolipoprotein B (19%, P=0.0071) and total cholesterol (12%, P=0.0374). 47% of AIS girls had at least one abnormal lipid value. Calorie intake and physical activity levels were similar between groups. However, compared to controls, there was a tendency for higher caloric balance (consumption vs. needs) in AIS girls (+60.5 ± 417.7 vs. −223.4 ± 625.7 kcal, P=0.1706). AIS girls and controls had similar vitamin D (4.60 ± 2.30 vs. 5.40 ± 3.01 μg, P=0.4469) and calcium intake (954.78 ± 326.20 vs. 928.78 ± 385.12 mg, P=0.8509). Conclusion : Our pilot study revealed tendencies for different anthropometrical features, lipid profile and energy balance in AIS. Increasing the number of participants might confirm these results. Support or Funding Information Fondation Yves Cotrel‐Institut de France This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".