DELETION OF PROTEIN TYROSINE PHOSPHATASE 1B PROTECTS AGAINST ENDOPLASMIC RETICULUM STRESS‐INDUCED ENDOTHELIAL DYSFUNCTION
Bibliographic record
Abstract
Protein Tyrosine Phosphatase 1B (PTP1B) modulates endoplasmic reticulum stress (ERS). However, whether PTP1B regulates ERS‐nduced endothelial dysfunction is unknown. To test the hypothesis that PTP1B deletion protects against ERS‐mediated endothelial dysfunction, ERS was induced with either tunicamycin (TUNICA) in aortic rings from PTP1B null (KO) and control mice (WT) or by treating WT and KO mice with STZ for 4 weeks. Assessment of the vascular function demonstrated that TUNICA reduced endothelial function by 30% in WT mice while endothelial function remained intact in KO mice. ACh relaxation was completely abolished by LNAME but neither tempol nor indomethacin improved ERS‐mediated endothelial dysfunction, suggesting that neither ROS nor COX derivatives are involved in the dysfunction. TUNICA blunted Ca2+‐mediated relaxation in WT mice only, suggesting that PTP1B deletion preserves eNOS sensitivity to Ca2+. Four weeks of STZ treatment significantly reduced endothelial function in WT mice. Acute treatment of aortic rings with the ERS inhibitor TUDCA restored endothelial function and confirmed that type I diabetes induces endothelial dysfunction via ERS. Despite a higher glycemia compared to WT mice, PTP1B KO mice did not develop an endothetlial dysfunction in response to STZ and TUDCA did not affect vascular relaxation. Consequently, PTP1B appears to be a key target to prevent endothelial function.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".