Effects of Home‐Based Exercise Training on Post‐Exercise Peripheral Muscle Oxygenation in Children with Congenital Heart Disease
Bibliographic record
Abstract
A hallmark feature of children with congenital heart disease (CHD) is exercise intolerance, along with slow post‐exercise muscle oxygenation recovery. Exercise rehabilitation programs have been shown to improve peak V̇O 2 in children with CHD; however, exercise tolerance is still limited compared to healthy matched controls. Whether exercise training improves post‐exercise recovery of muscle oxygenation (as measured by tissue oxygenation index, TOI) in children with CHD compared to healthy children is unknown. PURPOSE To determine whether a 12‐week home‐based exercise intervention can improve post‐exercise TOI response after peak exercise in children with CHD compared to controls. METHODS Eight children with CHD (f/m = 4/4; mean ± SD age: 12 ± 2 yrs) with simple and complex lesions and seven healthy controls (f/m = 3/4; age: 12 ± 3 yrs) were studied. Children with CHD completed a home‐based exercise program 3 times/week for 12 weeks, in addition to 6 biweekly in‐person sessions. Exercise tolerance was assessed with peak V̇O 2 testing to volitional fatigue on a cycle ergometer, followed by 4 minutes of 20‐W recovery. Vastus lateralis TOI was continuously sampled during exercise and recovery via near‐infrared spectroscopy. Post‐exercise TOI recovery data was normalized from 0% (end‐exercise) to 100% (4 min post‐exercise) and data analyzed at set time points to characterize TOI time course changes (0s, 15s, 30s, 60s, 90s, 120s, 180s and 240s). Pre vs. post training changes in TOI were analyzed using paired t ‐tests. Significance was accepted when P <0.05. RESULTS Post‐exercise TOI was significantly lower in CHD pre‐training compared to controls at 15s (9 ± 9 vs. 27 ± 16 %; P = 0.018) and 30s (32 ± 17 vs. 72 ± 35%; P = 0.012). Similarly, post‐exercise TOI in CHD after exercise training was significantly lower than controls at 15s (9 ± 7 vs. 27 ± 16 %; P = 0.014) and 30s (36 ± 22 vs. 72 ± 35%; P = 0.030)‐‐‐. CONCLUSION Excessive post‐exercise impairment in TOI recovery persists after home‐based exercise in children with CHD compared to controls. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".