Integrating cAMP and phospholipid signaling: role of phosphodiesterase 3B
Bibliographic record
Abstract
Cyclic AMP (cAMP) is a ubiquitous intracellular messenger that acts to integrate and translate the information encoded by extracellular messenger molecules, including hormones and neurotransmitters. Indeed, numerous extracellular messengers act to modulate cellular functions by altering the intracellular level of cAMP through increasing the rate of cAMP synthesis by adenylyl cyclases (ACs) or the rate of cAMP hydrolysis by cyclic nucleotide phosphodiesterases (PDEs). While early models proposed that cAMP was uniformly distributed throughout the cell, recent evidence is consistent with the idea that anchoring PDEs to selective subcellular locals may allow control of individual isolated subcellular pools of cAMP. In these studies, we demonstrate that human PDE3B can be targeted to distinct subcellular structures involved in regulating cAMP effects in hematopoietic cell lines, and that this signaling complex regulates the activity of a cAMP‐activated phospholipase C, PLC‐epsilon. In addition, this work is consistent with the novel idea that the regulation of PLC‐epsilon by PDE3B is mediated through effects on the activity of the exchange proteins activated by cAMP (EPACs), and not the more prototyipcal cAMP effector Protein Kinse A (PKA). Our data are presented in the context of PDE3B expression within a multi‐protein cellular complex and indicates PDE‐inhibitor effects in these cells. Funded by HSFO & CIHR
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".