Remodelling of the sympathetic nervous system following peripheral inflammation
Bibliographic record
Abstract
Remodelling of the sympathetic innervation of the colon occurs during inflammatory bowel disease (IBD). However, the mechanisms are unclear. We hypothesized that interleukin (IL)-17A, a key cytokine in IBD pathogenesis, plays a role in this remodelling. Chronic DSS-induced colitis in mice and immunohistochemistry were used to study sympathetic neuroplasticity. Sympathetic neurite outgrowth was examined from superior mesenteric ganglia (SMG) neurons cultured in the presence of IL-17A. Electrophysiology and Ca2+ imaging techniques were also used. Colitis enhanced sympathetic innervation of the colonic myenteric plexus and mucosa. Glial inhibition and explant studies suggest that IL-17A acts directly on axons to promote SMG outgrowth. Incubation of SMG neurons in IL-17A reduced voltage-gated Ca2+ current (ICa) and depolarisation-induced Ca2+ influx in growth cones. This effect was abrogated by an inhibitor of NF-κB signalling which also prevented IL-17A-induced neurite outgrowth. Blockade of ICa with a VGC channel blocker reproduced the effects of IL-17A on axonal outgrowth. Therefore, IL-17A may contribute to sympathetic remodelling during IBD through activation of NF-κB and inhibition of Ca2+ influx.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".