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Facial nerve morphogenesis: three‐dimensional and multiplanar study

2019· article· en· W3174967555 on OpenAlexaboutno aff
Marc Labrousse, Xavier Dubernard, Nicla Settembre, Emilien Micard, Marc Braun, Yohann Renard

Bibliographic record

VenueThe FASEB Journal · 2019
Typearticle
Languageen
FieldMedicine
TopicFacial Nerve Paralysis Treatment and Research
Canadian institutionsnot available
Fundersnot available
KeywordsGeniculate ganglionAnatomyFacial nerveMorphogenesisEmbryologyComputer scienceMedicineBiologyPathology

Abstract

fetched live from OpenAlex

The purpose of this study was to describe the facial nerve embryology, using three‐dimensional reconstructions from human embryos histological sections, and to compare our results with literature. Human embryos stage 13 to 21 from Carnegie collection and Paris‐Descartes University's Delmas‐Rouvière collection stained with hematoxylin & eosin or Masson's trichrome were used. A local made computer software developed by IADI lab (INSERM U947, Nancy) allowed automatic slices selection, automatic rigid registration, and dust filtering. Once registration had been completed, DICOM files were used with ORS Visual software (v1.5, Montreal), which allowed multiple display and post‐processing possibilities (3D VR; orthogonal/curved multiplanar reformation). Due to large size files, image processing was performed on PC with Windows 7 (64 bit) and 20 GB RAM. Three‐dimensional and multiplanar study of the facial nerve morphogenesis was possible with appropriate thresholding. The size, shape and positional changes of the facial nerve, geniculate ganglion, greater petrosal nerve and chorda tympanic relative to the external and middle ear were studied. Human embryonic facial nerve morphogenesis works are very rare because of the smallness of this anatomical structure. Our study using historic human embryos histological sections has shown the facial nerve growth. The precise knowledge of this morphogenesis will help to better understand congenital malformations. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.066
Threshold uncertainty score0.518

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.032
GPT teacher head0.300
Teacher spread0.267 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2019
Admission routes1
Has abstractyes

Explore more

Same venueThe FASEB JournalSame topicFacial Nerve Paralysis Treatment and ResearchFrench-language works237,207