Protein phosphatase 2A‐B56 controls mitosis by interacting with LS/TPI/V motif containing protein interactors
Bibliographic record
Abstract
Mitosis, like many other cellular processes, is tightly regulated by reversible protein phosphorylation which is achieved by coordinated activities of mitotic protein kinases and mitotic protein phosphatases. PP2A‐B56 is an important mitotic protein phosphatase which contributes to the timely execution of several mitotic events. Recent proteomic studies show that PP2A‐B56 recognizes a short linear motif, LXXIXE, on its interactors. We hypothesize that LS/TPI/V is a consensus motif for the recruitment of PP2A‐B56 in an isoform‐dependent manner, particularly during mitosis. We also speculate that this motif is phosphorylated during mitosis and dephosphorylated at mitotic exit. Recruitment of PP2A‐B56 is regulated by the phosphorylation status of this motif and this, in turn, plays an important role in controlling the progression of the cell cycle. Our findings show that LS/TPI/V motif is present in more than 100 mitotic regulators and several of them interact with PP2A‐B56 in a phosphorylation‐dependent and isoform‐dependent manner. Further understanding of how interactions between the target proteins and PP2A‐B56 affect mitotic progression and/or mitotic exit will provide valuable insight into the mechanisms of specific recruitment and mitotic functions of PP2A‐B56. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".