1288-PUB: Acute Inflammatory Response of Breaking Up Prolonged Sitting with Stair Climbing Exercise Snacks
Bibliographic record
Abstract
Understand the acute inflammatory disturbances is important for preventing early diabetes and obesity-related complications. This study aimed to determine whether breaking up prolonged sitting into brief several shorter bouts spread throughout the day (“exercise snacks”) associated a short-term dietary intervention (low- or high-carbohydrate) have the potential to alter the acute inflammatory response. Ten male and female healthy weight (Lean) and overweight-obese (OW) participants were randomized to non-training control group with either low-carbohydrate snack (9h sitting; LC) or matched for total energy high-carbohydrate snacks consumption (9h; sitting) and a high-carbohydrate snacks consumption plus stair-climbing intervention (8X15-30seconds; ACTIVE). The same high-glycemic index meals were consumed at 0, 3 and 6h at each condition. Blood samples were collected at baseline, 180, 360 and 540 minutes to assess Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α) and Salivary Immunoglobulin A (SIgA) levels. Mixed models for repeated measures were undertaken to examine differences according to condition x time and with Bonferroni post-hoc test. Change in TNF-α levels was not different within or between conditions from both Lean and OW group (p=0.512). For IL-6 there were a main effect of time at 540min [X2(11)=23.15; p=0.01] only in HC condition for OW group. Regarding to SIgA, Lean group showed higher level of SIgA on Active compared to LC and HC condition in all time-points (p=0.001). In addition, adults with OW showed elevated SIgA levels on LC and HC condition (p=0.001) when compared with same condition from Lean group. Our data suggests that breaking up nine hours of prolonged sitting implicated in reduction of acute inflammatory IL-6 plasma levels. In addition, acute manipulation on diet (low- and high-carbohydrate) resulted in alterations in the response of SIgA, increasing its levels in overweight/obese adults. Disclosure C. Cabral-santos: None. H. Rafiei: None. F. S. Lira: None. J. P. Little: None. Funding Natural Sciences and Engineering Research Council of Canada; Fundação de Amparo a Pesquisa do Estado de São Paulo (2018/17648-7)
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".