Dose‐response of leucine oxidation with beef feeding in middle‐aged men
Bibliographic record
Abstract
The current RDA for protein for older individuals is 0.8g/kg/day, however, some research has suggested this requirement may be higher. Our aim was to assess the acute effects of feeding and resistance exercise on leucine oxidation with graded quantities of ingested beef. Design 36 healthy older men (58.9 ± 5.2 yr, 1.75 ± 0.1 m, 82.6 ± 12.7 kg) reported to the laboratory in the post‐absorptive state. Catheters were inserted in an antecubital vein to infuse stable isotope labeled leucine ‐ [1‐ 13 C]. Subjects performed an intense bout of unilateral knee extension resistance exercise. After exercise, participants were randomly assigned to one of four feeding conditions, which included 0, 57, 113, or 170 g of beef. Protein synthesis and whole body leucine oxidation were measured over 4 h after exercise by collection of expired labeled CO 2 and plasma α‐ketoisocaproic acid and the reciprocal pool model. Results Leucine oxidation was significantly increased when 170 g of beef was ingested. This amount of dietary protein is in excess of what may be incorporated into tissue protein, which results in irreversible oxidation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".