Localization of nuclear and membrane progesterone receptors in the brainstem of adult mice
Bibliographic record
Abstract
We used immunohistochemistry to determine the localization of progesterone receptors (PR) in respiratory‐related areas in the brainstem of adult male mice. Serial slices were incubated with antibodies against nuclear PR (nPR), or membrane α and β PR (mPRα and mPRβ). A prominent staining for nPR, mPRα, and mPRβ appeared in caudal and rostral parts of the nucleus tractus solitarius (NTS), X and XII nuclei, but while nPR and mPRα stained cell bodies, mPRβ stained fibers. With double fluorescence labeling we showed that mPRα is co‐localized in catecholaminergic neurons (TH + ) in NTS, and in motoneurons in X and XII nuclei (VGLUT2 + ). mPRβ is expressed in TH + and VGLUT2 + fibers in these regions. A dense staining for nPR and mPRβ appeared in the ventrolateral medulla, in a region corresponding to the pre‐botzinger complex, and 3β‐HSD (an enzyme involved in progesterone synthesis) was also densily expressed in these regions. This suggests that local progesterone synthesis modulate respiratory function.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".