Central blockade of aldosterone synthase (AS) and lesion of the subfornical organ (SFO) attenuate subcutaneous (sc) aldosterone‐induced hypertension
Bibliographic record
Abstract
Central blockade of mineralocorticoid receptors (MR) prevents sc aldosterone (aldo) induced hypertension. We examined whether the SFO and aldo synthesized locally in the brain mediate sc aldo - induced hypertension. Wistar rats with telemetry probes were treated with icv infusion of AS inhibitor FAD286 (25 μg/d); icv eplerenone (5 μg/d); or icv vehicle. After 2 d, sc infusion of aldo (1 μg/h) was started and 0.9% saline given as drinking water for all. One extra group of rats was given saline without sc aldo. In a 2nd set of rats with telemetry, electrolytic lesions/sham lesions of the SFO were performed and sc aldo and saline started 1 wk after. Three wk after sc aldo, rats were decapitated and brain and trunk blood collected. Inhibition of AS, MR blockade, and SFO lesions attenuated sc aldo -induced pressor responses by ~60%. These results suggest that the SFO plays a crucial role in sc aldo induced hypertension possibly by responding to circulating aldo and relaying signals to increase local production of aldo and activate aldo-MR neuromodulatory pathways. Data=means± SE (n=5–9/group). *p<0.05, vs. others, a:p<0.05, vs. vehicle or sham lesion. (Supported by grant # FRN:MOP-74432 from the Canadian Institutes of Health Research)
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".