K/BxN‐induced poly‐arthritis is exacerbated by infection with the intestinal helminth parasite <i>Hymenolepis diminuta</i> ; possible involvement of complement and mast cells
Bibliographic record
Abstract
We examined the effect of Hymenolepis diminuta (H.D.) infection on a model of polyarthritis, to determine if helminth therapy modulates joint inflammation. BALB/c mice were untreated or infected with 10 H.D. cysticercoids. After 8 days, polyarthritis was induced and joint swelling was measured for 13 days. At necropsy, joints and serum were collected for analysis. K/BxN treatment induced swelling of all joints compared to vehicle treatment. Front paws and knees of H.D. infected mice were significantly more swollen than those of non‐infected K/BxN‐treated mice. This was accompanied by significant increases in serum complement C5a and mast cell protease‐1 in H.D. + K/BxN‐treated mice on day 2 compared to control and K/BxN‐only treated mice. Thus, exacerbated inflammation is paralleled by evidence of increased mast cell activation in H.D. + K/BxN treated mice. Mast cell activation is crucial in the K/BxN model and increased activation may underlie the exacerbation of disease by H.D.. Our data indicate that autoimmune pathways may be differentially sensitive to helminth therapy. Research was conducted with the support of Foreign Affairs and International Trade Canada and a CIHR operating grant.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".