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Record W3175868284 · doi:10.1016/s2352-3018(21)00071-0

Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis: week 96 results from a randomised, double-blind, placebo-controlled, phase 3 trial

2021· article· en· W3175868284 on OpenAlexaff
Onyema Ogbuagu, Peter Ruane, Daniel Podzamczer, Laura Salazar, Keith Henry, David M. Asmuth, David A. Wohl, Richard Gilson, Yongwu Shao, Ramin Ebrahimi, Stephanie Cox, Alexander Kintu, Christoph C Carter, Moupali Das, Jared M. Baeten, Diana M. Brainard, Gary Whitlock, Jason Brunetta, Gitte Kronborg, Christoph D. Spinner, Andrea Antinori, Vanessa Apea, Ann Avery, Paul Benson, Colm Bergin, Mezgebe Berhe, Indira Brar, Cynthia Brinson, Jeffrey H. Burack, Thomas L. Campbell, Michelle Cespedes, Amanda Clarke, Megan Coleman, J Coll, Manuel Crespo Casal, Catherine Creticos, Gordon Crofoot, Frederick Cruickshank, Éric Cua, Eric S. Daar, Joseph de Wet, Edwin DeJesus, William D. Dinges, Susanne Doblecki‐Lewis, Taylor Donovan, Olamide Dosekun, Jason Flamm, Joel E. Gallant, Jan Gerstoft, Jay Gladstein, Robert M. Grant, Robert Grossberg, Bernhard Haas, Jason Halperin, William D. Hardy, C. Bradley Hare, Shawn Hassler, Richard L. Hengel, William Henry, Theo Hodge, Sybil Hosek, Chris Hurt, Michelle Iandiorio, Heiko Jessen, Stephen Kegg, Gabriele Knecht, Ivanka Krznaric, Anthony LaMarca, Carsten Schade Larsen, Olav Larsen, Adriano Lazzarin, Clifford Leen, Christopher Lucasti, Patrick Mallon, Sharon Mannheimer, Martin Markowitz, Claudia Martorell, Kenneth Mayer, Anthony Mills, Jean‐Michel Molina, Sheldon Morris, Karam Mounzer, Nneka Nwokolo, Olayemi Osiyemi, Andrew E. Petroll, Patrick Philibert, John Phoenix, G. Pialoux, Frank A. Post, Maria Prins, Moti Ramgopal, Bruce Rashbaum, Iain Reeves, Gary Richmond, Armin Rieger, Anthony Scarsella, Gabriel Schembri, Mia Scott, Peter Shalit, Gary Sinclair, Magdalena E. Sobieszczyk, Jeffrey L. Stephens, Jason Szabo, Stephen Taylor, Melanie Thompson, Cécile Tremblay, Benoît Trottier, Gene W. Voskuhl, B Wade, Kimberly Workowski, Sigal Yawetz, Benjamin Young

Bibliographic record

VenueThe Lancet HIV · 2021
Typearticle
Languageen
FieldMedicine
TopicHIV/AIDS drug development and treatment
Canadian institutionsMaple Leaf Medical Clinic
FundersNational Institute of Allergy and Infectious DiseasesAbbVieGilead SciencesMerckEli Lilly and Company
KeywordsEmtricitabineMedicineTenofovir alafenamidePlaceboPre-exposure prophylaxisTenofovirHuman immunodeficiency virus (HIV)Randomized controlled trialPharmacologyInternal medicineAntiretroviral therapyMen who have sex with menVirologyViral loadAlternative medicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.008
Threshold uncertainty score0.026

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.003
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0040.004
Bibliometrics0.0000.000
Science and technology studies0.0010.001
Scholarly communication0.0020.002
Open science0.0010.000
Research integrity0.0030.005
Insufficient payload (model declined to judge)0.0080.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.027
GPT teacher head0.294
Teacher spread0.266 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations91
Published2021
Admission routes1
Has abstractno

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